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cDNA cloning of rat cardiotrophin-1 (CT-1): augmented expression of CT-1 gene in ventricle of genetically hypertensive rats.

Authors: Ishikawa, M  Saito, Y  Miyamoto, Y  Kuwahara, K  Ogawa, E  Nakagawa, O  Harada, M  Masuda, I  Nakao, K 
Citation: Ishikawa M, etal., Biochem Biophys Res Commun 1996 Feb 15;219(2):377-81.
Pubmed: (View Article at PubMed) PMID:8604995
DOI: Full-text: DOI:10.1006/bbrc.1996.0241

Cardiotrophin-1 (CT-1) is a novel cytokine that was discovered from mouse embryoid bodies by means of expression cloning. It induces hypertrophy in cultured myocytes by activating a gp130 signaling pathway. To investigate the expression of the CT-1 gene in both normal adult and genetically hypertensive rats, we cloned rat CT-1 cDNA. The amino acid sequence is 94% identical to that of mouse CT-1. A significant amount of CT-1 mRNA was expressed in the ventricle of adult rats and also detected in the lung, kidney, liver, skeletal muscle, stomach and urinary bladder. Northern blot analysis revealed that the CT-1 mRNA level is significantly augmented in the ventricle of 12-week-old spontaneously hypertensive rats-stroke prone/Izm at a stage of established hypertension, suggesting a possible relevance of CT-1 to ventricular hypertrophy.

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CRRD Object Information
CRRD ID: 69823
Created: 2002-01-09
Species: All species
Last Modified: 2002-01-09
Status: ACTIVE



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