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Expression and regulation of gamma-glutamyl transpeptidase-related enzyme in tracheal cells.

Authors: Potdar, PD  Andrews, KL  Nettesheim, P  Ostrowski, LE 
Citation: Potdar PD, etal., Am J Physiol 1997 Nov;273(5 Pt 1):L1082-9.
Pubmed: (View Article at PubMed) PMID:9374738

Glutathione plays an essential role in protecting the pulmonary system from toxic insults. gamma-Glutamyl transpeptidase-related enzyme (GGT-rel) is a novel protein capable of cleaving the gamma-glutamyl peptide bond of glutathione and of converting leukotriene C4 to leukotriene D4. A rat homologue of GGT-rel was identified and was found to be highly expressed in cultures of differentiating rat tracheal epithelial (RTE) cells. The 2.6-kb cDNA predicts a 572-amino acid protein with 79% identity to human GGT-rel. GGT-rel was weakly expressed in normal trachea but was strongly induced by epidermal growth factor in cultures of RTE cells. GGT-rel was also highly expressed in lung tumors induced by inhalation of isobutyl nitrite. These results demonstrate that GGT-rel 1) is expressed in normal tracheal cells, 2) can be induced by epidermal growth factor, and 3) is elevated after chemical exposure. The induction of high levels of GGT-rel may play an important role in protecting the lung from oxidative stress or other toxic insults.


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CRRD Object Information
CRRD ID: 69846
Created: 2002-01-09
Species: All species
Last Modified: 2002-01-09
Status: ACTIVE


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