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Cloning and characterization of a novel class VI semaphorin, semaphorin Y.

Authors: Kikuchi, K  Chedotal, A  Hanafusa, H  Ujimasa, Y  De Castro, F  Goodman, CS  Kimura, T 
Citation: Kikuchi K, etal., Mol Cell Neurosci 1999 Jan;13(1):9-23.
Pubmed: (View Article at PubMed) PMID:10049528
DOI: Full-text: DOI:10.1006/mcne.1998.0732

Semaphorins comprise a large family of proteins implicated in axonal guidance. We cloned a novel transmembrane semaphorin, semaphorin Y (Sema Y), which has a class VI sema domain. Sema Y shows growth cone collapsing activity on DRG neurons in vitro, and the target regions of the DRG neurons express sema Y mRNA during development. Sema Y may be a stop signal for these neurons in their target areas. Interestingly, sema Y mRNA was also detected in other neurons and their targets. Two isoforms of Sema Y derived from alternative splicing were identified and their expression was found to be regulated in a tissue- and age-dependent manner. Distribution of sema Y mRNA suggests that Sema Y might also be important during maintenance of axonal connections and/or differentiation and migration of cells. Sequence comparison among class VI semaphorins revealed two short conserved sequence stretches in their cytoplasmic domains, suggesting interaction of these semaphorins with a common intracellular component(s).


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CRRD Object Information
CRRD ID: 69992
Created: 2002-01-11
Species: All species
Last Modified: 2002-01-11
Status: ACTIVE


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