Floor plate and motor neuron induction by vhh-1, a vertebrate homolog of hedgehog expressed by the notochord.

Authors: Roelink, H  Augsburger, A  Heemskerk, J  Korzh, V  Norlin, S  Ruiz i Altaba, A  Tanabe, Y  Placzek, M  Edlund, T  Jessell, TM 
Citation: Roelink H, etal., Cell 1994 Feb 25;76(4):761-75.
Pubmed: (View Article at PubMed) PMID:8124714

The differentiation of distinct cell types in the ventral neural tube depends on local inductive signals from the notochord. We have isolated a vertebrate homolog of the Drosophila segment polarity gene hedgehog (hh) from zebrafish and rat, termed vhh-1. vhh-1 is expressed in the node, notochord, floor plate, and posterior limb bud mesenchyme. Each of these cell groups has floor plate inducing activity, suggesting that the vhh-1 gene may encode a floor plate-inducing molecule. Widespread expression of rat vhh-1 in frog embryos leads to ectopic floor plate differentiation in the neural tube. In vitro tests for the signaling functions of vhh-1 demonstrate that COS cells expressing the rat vhh-1 gene induce floor plate and motor neuron differentiation in neural plate explants. vhh-1 may, therefore, contribute to the floor plate and motor neuron inducing activities of the notochord.


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CRRD Object Information
CRRD ID: 69996
Created: 2002-01-11
Species: All species
Last Modified: 2002-01-11
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.