cDNA cloning and characterization of rat C5a anaphylatoxin receptor.

Authors: Akatsu, H  Miwa, T  Sakurada, C  Fukuoka, Y  Ember, JA  Yamamoto, T  Hugli, TE  Okada, H 
Citation: Akatsu H, etal., Microbiol Immunol 1997;41(7):575-80.
Pubmed: (View Article at PubMed) PMID:9272704

Activation of the complement cascade plays an essential role in the early stages of inflammation. C5a and its receptor are particularly active in anaphylaxis. To determine the pathological roles played by C5a and C5a receptor (C5aR) in rats, we cloned C5aR cDNA and analyzed distribution of its mRNA in various organs including lung from an LPS-stimulated rat. Furthermore, we generated a polyclonal antiserum which specifically recognizes rat C5aR, as confirmed by its specific interaction with cells transfected with rat C5aR cDNA.

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CRRD Object Information
CRRD ID: 70679
Created: 2002-06-18
Species: All species
Last Modified: 2002-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.