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A cGMP-signaling pathway in a subset of olfactory sensory neurons.

Authors: Meyer, MR  Angele, A  Kremmer, E  Kaupp, UB  Muller, F 
Citation: Meyer MR, etal., Proc Natl Acad Sci U S A 2000 Sep 12;97(19):10595-600.
Pubmed: (View Article at PubMed) PMID:10984544

It is well established that signal transduction in sensory neurons of the rat olfactory epithelium involves a cAMP-signaling pathway. However, a small number of olfactory neurons specifically express cGMP-signaling components, namely a guanylyl cyclase (GC-D) and a cGMP-stimulated phosphodiesterase (PDE2). Here, we show that this subset of olfactory neurons expressing GC-D and PDE2 does also express the subunit of a cGMP-selective cyclic nucleotide-gated (CNG) channel that has been previously identified in cone photoreceptors. Further, components of the prototypical cAMP-signaling pathway could not be detected in this subpopulation of cells. These results imply that these neurons use an alternative signaling pathway, with cGMP as the intracellular messenger, and that, in these cells, the receptor current is initiated by the opening of cGMP-gated channels.


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CRRD Object Information
CRRD ID: 70699
Created: 2002-06-18
Species: All species
Last Modified: 2002-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.