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A genomic-systems biology map for cardiovascular function.

Authors: Stoll, M  Cowley AW, JR  Tonellato, PJ  Greene, AS  Kaldunski, ML  Roman, RJ  Dumas, P  Schork, NJ  Wang, Z  Jacob, HJ 
Citation: Stoll M, etal., Science 2001 Nov 23;294(5547):1723-6.
Pubmed: (View Article at PubMed) PMID:11721057
DOI: Full-text: DOI:10.1126/science.1062117

With the draft sequence of the human genome available, there is a need to better define gene function in the context of systems biology. We studied 239 cardiovascular and renal phenotypes in 113 male rats derived from an F2 intercross and mapped 81 of these traits onto the genome. Aggregates of traits were identified on chromosomes 1, 2, 7, and 18. Systems biology was assessed by examining patterns of correlations ("physiological profiles") that can be used for gene hunting, mechanism-based physiological studies, and, with comparative genomics, translating these data to the human genome.


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CRRD Object Information
CRRD ID: 70849
Created: 2002-07-01
Species: All species
Last Modified: 2002-07-01
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.