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The diversity of calcium sensor proteins in the regulation of neuronal function.

Authors: McCue, HV  Haynes, LP  Burgoyne, RD 
Citation: McCue HV, etal., Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a004085. doi: 10.1101/cshperspect.a004085. Epub 2010 Jul 28.
Pubmed: (View Article at PubMed) PMID:20668007
DOI: Full-text: DOI:10.1101/cshperspect.a004085

Calcium signaling in neurons as in other cell types mediates changes in gene expression, cell growth, development, survival, and cell death. However, neuronal Ca(2+) signaling processes have become adapted to modulate the function of other important pathways including axon outgrowth and changes in synaptic strength. Ca(2+) plays a key role as the trigger for fast neurotransmitter release. The ubiquitous Ca(2+) sensor calmodulin is involved in various aspects of neuronal regulation. The mechanisms by which changes in intracellular Ca(2+) concentration in neurons can bring about such diverse responses has, however, become a topic of widespread interest that has recently focused on the roles of specialized neuronal Ca(2+) sensors. In this article, we summarize synaptotagmins in neurotransmitter release, the neuronal roles of calmodulin, and the functional significance of the NCS and the CaBP/calneuron protein families of neuronal Ca(2+) sensors.

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CRRD Object Information
CRRD ID: 7204681
Created: 2012-12-26
Species: All species
Last Modified: 2012-12-26
Status: ACTIVE



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