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Oral administration of a nonimmunosuppressant FKBP-12 ligand speeds nerve regeneration.

Authors: Gold, BG  Zeleny-Pooley, M  Chaturvedi, P  Wang, MS 
Citation: Gold BG, etal., Neuroreport. 1998 Feb 16;9(3):553-8.
Pubmed: (View Article at PubMed) PMID:9512405

We recently showed that s.c. injections of a nonimmunosuppressant FK506 binding protein-12 (FKBP-12) ligand (V-10,367) accelerates nerve regeneration in the rat sciatic nerve crush model. Here we examined the oral efficacy of this compound for speeding nerve regeneration. Rats receiving V-10,367 (5, 15 or 50 mg/kg/day) by oral gavage all demonstrated an increase in nerve regeneration compared to vehicle-treated controls. Functional recovery was observed earliest and axonal calibers of regenerating axons in the soleus nerve were largest in the 15 mg/kg group, mean axonal areas being increased by 66% compared to controls. Orally active nonimmunosuppressant FKBP-12 ligands may be useful for the treatment of human peripheral nerve disorders.


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CRRD Object Information
CRRD ID: 7205517
Created: 2013-01-08
Species: All species
Last Modified: 2013-01-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.