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Association of bone activity, calcium load, aortic stiffness, and calcifications in ESRD.

Authors: London, GM  Marchais, SJ  Guerin, AP  Boutouyrie, P  Metivier, F  De Vernejoul, MC 
Citation: London GM, etal., J Am Soc Nephrol. 2008 Sep;19(9):1827-35. doi: 10.1681/ASN.2007050622. Epub 2008 May 14.
Pubmed: (View Article at PubMed) PMID:18480316
DOI: Full-text: DOI:10.1681/ASN.2007050622

An inverse relationship between arterial calcifications and bone activity has been documented in patients with ESRD. Calcium overload is associated with arterial calcification, which is associated with arterial stiffening. Whether bone activity interacts with calcium load, aortic stiffness, or arterial calcification is unknown. This study assessed the impact of bone activity on the relationships between the dosage of calcium-containing phosphate binders and aortic stiffness (measured by pulse wave velocity) or abdominal aorta calcification score. Aortic stiffness and calcification were both positively associated with calcium load and negatively associated with bone activity. A significant interaction was found between dosage of calcium-containing phosphate binders and bone activity such that calcium load had a significantly greater influence on aortic calcifications and stiffening in the presence of adynamic bone disease. Independent of any other factor, including dosage of calcium-containing phosphate binders, adynamic bone was associated with greater aortic stiffening, suggesting cross-talk between the bone and arterial walls.


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CRRD Object Information
CRRD ID: 7242687
Created: 2013-04-16
Species: All species
Last Modified: 2013-04-16
Status: ACTIVE


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