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Cardioprotection by Klotho through downregulation of TRPC6 channels in the mouse heart.

Authors: Xie, J  Cha, SK  An, SW  Kuro-o, M  Birnbaumer, L  Huang, CL 
Citation: Xie J, etal., Nat Commun. 2012;3:1238. doi: 10.1038/ncomms2240.
Pubmed: (View Article at PubMed) PMID:23212367
DOI: Full-text: DOI:10.1038/ncomms2240

Klotho is a membrane protein predominantly produced in the kidney that exerts some antiageing effects. Ageing is associated with an increased risk of heart failure; whether Klotho is cardioprotective is unknown. Here we show that Klotho-deficient mice have no baseline cardiac abnormalities but develop exaggerated pathological cardiac hypertrophy and remodelling in response to stress. Cardioprotection by Klotho in normal mice is mediated by downregulation of TRPC6 channels in the heart. We demonstrate that deletion of Trpc6 prevents stress-induced exaggerated cardiac remodelling in Klotho-deficient mice. Furthermore, mice with heart-specific overexpression of TRPC6 develop spontaneous cardiac hypertrophy and remodelling. Klotho overexpression ameliorates cardiac pathologies in these mice and improves their long-term survival. Soluble Klotho present in the systemic circulation inhibits TRPC6 currents in cardiomyocytes by blocking phosphoinositide-3-kinase-dependent exocytosis of TRPC6 channels. These results provide a new perspective on the pathogenesis of cardiomyopathies and open new avenues for treatment of the disease.


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CRRD Object Information
CRRD ID: 7247443
Created: 2013-07-16
Species: All species
Last Modified: 2013-07-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.