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A nuclear pore complex protein that contains zinc finger motifs, binds DNA, and faces the nucleoplasm.

Authors: Sukegawa, J  Blobel, G 
Citation: Sukegawa J and Blobel G, Cell 1993 Jan 15;72(1):29-38.
Pubmed: (View Article at PubMed) PMID:8422679

We have molecularly cloned and sequenced a cDNA for a rat liver nucleoporin with a molecular mass of 152.8 kd, termed nup153, that shares a repetitive degenerate pentapeptide motif with a subgroup of nucleoporins of yeast and vertebrates. However, its most striking feature is a novel 4-fold repeat of a Cys2-Cys2-type zinc finger motif. When expressed in E. coli, the zinc finger domain of nup153 binds DNA in a zinc-dependent fashion. Immunoelectron microscopy localized nup153 exclusively to the nucleoplasmic side of the nuclear pore complex. We suggest that nup153 recognizes a specific DNA sequence to organize the genome three-dimensionally and to gate transcribable genes to nuclear pore complexes.


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CRRD Object Information
CRRD ID: 729043
Created: 2003-11-25
Species: All species
Last Modified: 2003-11-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.