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A P2X purinoceptor expressed by a subset of sensory neurons.

Authors: Chen, CC  Akopian, AN  Sivilotti, L  Colquhoun, D  Burnstock, G  Wood, JN 
Citation: Chen CC, etal., Nature 1995 Oct 5;377(6548):428-31.
Pubmed: (View Article at PubMed) PMID:7566119
DOI: Full-text: DOI:10.1038/377428a0

ATP is known to depolarize sensory neurons, and may play a role in nociceptor activation when released from damaged tissue. Here we report the molecular cloning and characterization of a new member of the P2X receptor family, P2X3, expressed by these cells. The channel transcript was present in a subset of rat dorsal-root-ganglion sensory neurons, some of which express nociceptor-associated markers; it was absent in other tissues that were tested, including sympathetic, enteric and central nervous system neurons. Moreover, when expressed in Xenopus oocytes, the channel showed an ATP-dependent cation flux. P2X3 is the only ligand-gated channel known to be expressed exclusively by a subset of sensory neurons. The remarkable selectivity of expression of the channel coupled with its sensory neuron-like pharmacology suggests that this channel may transduce ATP-evoked nociceptor activation.

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CRRD Object Information
CRRD ID: 729168
Created: 2003-11-25
Species: All species
Last Modified: 2003-11-25
Status: ACTIVE



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