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Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain.

Authors: Lemaigre, FP  Durviaux, SM  Truong, O  Lannoy, VJ  Hsuan, JJ  Rousseau, GG 
Citation: Lemaigre FP, etal., Proc Natl Acad Sci U S A 1996 Sep 3;93(18):9460-4.
Pubmed: (View Article at PubMed) PMID:8790352

Tissue-specific transcription is regulated in part by cell type-restricted proteins that bind to defined sequences in target genes. The DNA-binding domain of these proteins is often evolutionarily conserved. On this basis, liver-enriched transcription factors were classified into five families. We describe here the mammalian prototype of a sixth family, which we therefore call hepatocyte nuclear factor 6 (HNF-6). It activates the promoter of a gene involved in the control of glucose metabolism. HNF-6 contains two different DNA-binding domains. One of these corresponds to a novel type of homeodomain. The other is homologous to the Drosophila cut domain. A similar bipartite sequence is coded by the genome of Caenorhabditis elegans.


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CRRD Object Information
CRRD ID: 729198
Created: 2003-11-25
Species: All species
Last Modified: 2003-11-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.