Autoimmune encephalomyelitis and uveitis induced by T cell immunity to self beta-synuclein.

Authors: Mor, F  Quintana, F  Mimran, A  Cohen, IR 
Citation: Mor F, etal., J Immunol 2003 Jan 1;170(1):628-34.
Pubmed: (View Article at PubMed) PMID:12496452

Beta-synuclein is a neuronal protein that accumulates in the plaques that characterize neurodegenerative diseases such as Parkinson's and Alzheimer's diseases. It has been proposed that immunization to peptides of plaque-forming proteins might be used therapeutically to help dissociate pathogenic plaques in the brain. We now report that immunization of Lewis rats with a peptide from beta-synuclein resulted in acute paralytic encephalomyelitis and uveitis. T cell lines and clones reactive to the peptide adoptively transferred the disease to naive rats. Immunoblotting revealed the presence of beta-synuclein in heavy myelin, indicating that the expression of beta-synuclein is not confined to neurons. These results add beta-synuclein to the roster of encephalitogenic self Ags, point out the potential danger of therapeutic autoimmunization to beta-synuclein, and alert us to the unsuspected possibility that autoimmunity to beta-synuclein might play an inflammatory role in the pathogenesis of neurodegeneration.

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CRRD Object Information
CRRD ID: 730073
Created: 2003-12-01
Species: All species
Last Modified: 2003-12-01
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.