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Isolation of two novel genes, down-regulated in gastric cancer.

Authors: Yoshikawa, Y  Mukai, H  Hino, F  Asada, K  Kato, I 
Citation: Yoshikawa Y, etal., Jpn J Cancer Res 2000 May;91(5):459-63.
Pubmed: (View Article at PubMed) PMID:10835488

Using a differential display technique, we identified two genes that are down-regulated in human gastric cancer tissue as compared to normal gastric mucosa. The down-regulated expression of these genes in gastric cancer tissue was confirmed by northern blotting analysis and RT-PCR. One, CA11, was a novel gene expressed predominantly in the stomach and was depleted in all of the gastric cancer cell lines examined. The other gene, GC36, was homologous to the digestive tract-specific calpain gene, nCL-4. The expression of both GC36 and nCL-4 was suppressed or depleted in gastric cancer cell lines of differentiated and poorly differentiated types. This is the first report of genes, the expression of which is down-regulated with considerable frequency in gastric cancer.


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CRRD Object Information
CRRD ID: 734688
Created: 2004-02-03
Species: All species
Last Modified: 2004-02-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.