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Osteopetrosis and osteoporosis: two sides of the same coin.

Authors: Lazner, F  Gowen, M  Pavasovic, D  Kola, I 
Citation: Lazner F, etal., Hum Mol Genet 1999;8(10):1839-46.
Pubmed: (View Article at PubMed) PMID:10469835

Together, osteoporosis and osteopetrosis comprise a substantial proportion of the bone diseases that severely affect humans. In order to understand and effectively treat these disorders, an understanding of the mechanisms controlling bone remodelling is essential. While numerous animal models of bone disease have been generated, the lack of correlation between these animal models and human disease has limited their utility in terms of defining therapeutic strategies. The generation and analysis of cathepsin K knockout mice has resulted in a model for pycnodysostosis, a rare human osteopetrotic disease, and is now providing considerable insights into both osteoclast function and potential therapeutic strategies for the treatment of bone disease. This review highlights the importance of genes such as cathepsin K in understanding bone remodelling and illustrates a new trend towards understanding bone disease as a complete entity rather than as a series of unrelated disorders.

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CRRD Object Information
CRRD ID: 734856
Created: 2004-02-03
Species: All species
Last Modified: 2004-02-03
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.