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SNAP family of NSF attachment proteins includes a brain-specific isoform.

Authors: Whiteheart, SW  Griff, IC  Brunner, M  Clary, DO  Mayer, T  Buhrow, SA  Rothman, JE 
Citation: Whiteheart SW, etal., Nature 1993 Mar 25;362(6418):353-5.
Pubmed: (View Article at PubMed) PMID:8455721
DOI: Full-text: DOI:10.1038/362353a0

The soluble NSF attachment proteins (SNAPs) enable N-ethyl-maleimide-sensitive fusion protein (NSF) to bind to target membranes. Here we report the cloning and sequencing of complementary DNAs encoding alpha-, beta- and gamma-SNAPs. Two of these proteins, alpha and gamma, are found in a wide range of tissues, and act synergistically in intra-Golgi transport. The third, beta, is a brain-specific isoform of alpha-SNAP. Thus, NSF and SNAPs appear to be general components of the intracellular membrane fusion apparatus, and their action at specific sites of fusion must be controlled by SNAP receptors particular to the membranes being fused, as described in the accompanying article.


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CRRD Object Information
CRRD ID: 737634
Created: 2004-02-08
Species: All species
Last Modified: 2004-02-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.