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A transforming growth factor beta type I receptor that signals to activate gene expression.

Authors: Bassing, CH  Yingling, JM  Howe, DJ  Wang, T  He, WW  Gustafson, ML  Shah, P  Donahoe, PK  Wang, XF 
Citation: Bassing CH, etal., Science 1994 Jan 7;263(5143):87-9.
Pubmed: (View Article at PubMed) PMID:8272871

Transforming growth factor beta (TGF-beta) is a multifunctional factor that regulates many aspects of cellular functions. TGF-beta signals through a heteromeric complex of the type I and type II TGF-beta receptors. However, the molecular mechanism of signal transduction by this receptor complex remains unresolved. The type II receptor belongs to a transmembrane receptor serine-threonine kinase family. A new member of this receptor family (R4) was identified and shown to be a functional TGF-beta type I receptor on the basis of its ability to restore a TGF-beta-induced gene response in mutant cell lines lacking endogenous type I receptor. Both ligand binding and signaling of the R4 protein were dependent on the presence of a functional type II receptor. The type I receptor has an intrinsic serine-threonine kinase activity, which was essential for signal transduction.


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CRRD Object Information
CRRD ID: 737663
Created: 2004-02-18
Species: All species
Last Modified: 2004-02-18
Status: ACTIVE


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