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Annexin A1 attenuates EMT and metastatic potential in breast cancer.

Authors: Maschler, S  Gebeshuber, CA  Wiedemann, EM  Alacakaptan, M  Schreiber, M  Custic, I  Beug, H 
Citation: Maschler S, etal., EMBO Mol Med. 2010 Oct;2(10):401-14. doi: 10.1002/emmm.201000095.
Pubmed: (View Article at PubMed) PMID:20821804
DOI: Full-text: DOI:10.1002/emmm.201000095

Metastasis is the major cause of carcinoma-induced death, but mechanisms involved are poorly understood. Metastasis crucially involves epithelial-to-mesenchymal transition (EMT), causing loss of epithelial polarity. Here we identify Annexin A1 (AnxA1), a protein with important functions in intracellular vesicle trafficking, as an efficient suppressor of EMT and metastasis in breast cancer. AnxA1 levels were strongly reduced in EMT of mammary epithelial cells, in metastatic murine and human cell lines and in metastatic mouse and human carcinomas. RNAi-mediated AnxA1 knockdown cooperated with oncogenic Ras to induce TGFbeta-independent EMT and metastasis in non-metastatic cells. Strikingly, forced AnxA1 expression in metastatic mouse and human mammary carcinoma cells reversed EMT and abolished metastasis. AnxA1 knockdown stimulated multiple signalling pathways but only Tyk2/Stat3 and Erk1/2 signalling were essential for EMT.

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CRRD Object Information
CRRD ID: 7421541
Created: 2013-11-20
Species: All species
Last Modified: 2013-11-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.