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Annexin A1 regulates TGF-beta signaling and promotes metastasis formation of basal-like breast cancer cells.

Authors: De Graauw, M  Van Miltenburg, MH  Schmidt, MK  Pont, C  Lalai, R  Kartopawiro, J  Pardali, E  Le Devedec, SE  Smit, VT  Van der Wal, A  Van't Veer, LJ  Cleton-Jansen, AM  Ten Dijke, P  Van de Water, B 
Citation: de Graauw M, etal., Proc Natl Acad Sci U S A. 2010 Apr 6;107(14):6340-5. doi: 10.1073/pnas.0913360107. Epub 2010 Mar 22.
Pubmed: (View Article at PubMed) PMID:20308542
DOI: Full-text: DOI:10.1073/pnas.0913360107

Annexin A1 (AnxA1) is a candidate regulator of the epithelial- to mesenchymal (EMT)-like phenotypic switch, a pivotal event in breast cancer progression. We show here that AnxA1 expression is associated with a highly invasive basal-like breast cancer subtype both in a panel of human breast cancer cell lines as in breast cancer patients and that AnxA1 is functionally related to breast cancer progression. AnxA1 knockdown in invasive basal-like breast cancer cells reduced the number of spontaneous lung metastasis, whereas additional expression of AnxA1 enhanced metastatic spread. AnxA1 promotes metastasis formation by enhancing TGFbeta/Smad signaling and actin reorganization, which facilitates an EMT-like switch, thereby allowing efficient cell migration and invasion of metastatic breast cancer cells.


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CRRD Object Information
CRRD ID: 7421563
Created: 2013-11-21
Species: All species
Last Modified: 2013-11-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.