Apolipoprotein E promoter polymorphisms do not have a major influence on the risk of developing primary open angle glaucoma.

Authors: Ressiniotis, T  Griffiths, PG  Birch, M  Keers, SM  Chinnery, PF 
Citation: Ressiniotis T, etal., Mol Vis. 2004 Oct 28;10:805-7.
Pubmed: (View Article at PubMed) PMID:15525904

PURPOSE: Primary open angle glaucoma (POAG) is a major cause of late onset visual failure of unknown etiology. Recent genetic association studies have implicated the apolipoprotein E (APOE) gene in the pathophysiology of primary open angle glaucoma, but there have been conflicting findings. METHODS: To resolve this issue we studied 140 cases and 73 controls that were carefully phenotyped, and used a logistic regression model to simultaneously analyze the effect of apolipoprotein E genotype and functional polymorphisms in the apolipoprotein E gene promoter while controlling for potentially confounding variables. RESULTS: We found no evidence of an association between the apolipoprotein E promoter region polymorphisms and primary open angle glaucoma. CONCLUSIONS: Apolipoprotein E promoter polymorphisms are unlikely to have a major impact on the pathophysiology of primary open angle glaucoma.


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CRRD Object Information
CRRD ID: 7495787
Created: 2013-12-13
Species: All species
Last Modified: 2013-12-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.