Lack of evidence for association between endothelial nitric oxide synthase gene polymorphism (glu298asp) with Behcet's disease in the Turkish population.

Authors: Kara, N  Senturk, N  Gunes, SO  Bagci, H  Yigit, S  Turanli, AY 
Citation: Kara N, etal., Arch Dermatol Res. 2006 Apr;297(10):468-71. Epub 2006 Feb 7.
Pubmed: (View Article at PubMed) PMID:16463158
DOI: Full-text: DOI:10.1007/s00403-006-0643-7

Endothelial nitric oxide synthase (eNOS) could be a candidate gene for Behcet's disease (BD). This study investigated the relationship of the eNOS Glu298 --> Asp polymorphism with the presence and severity of BD in the Turkish population. Ninety-two patients with BD and 100 controls were studied. Analyses of Glu298Asp polymorphism in exon 7 of the eNOS gene were made by the polymerase chain reaction (PCR)-restriction fragment length polymorphism technique. The frequencies of the eNOS genotypes were similar for BD patients (GG:GT:TT = 58.7%:38%:3.3%) and controls (59.2%:33.7%:7.1 %), P = 0.335. No evidence of difference was found in the frequency of the T allele between BD patients (22.3%) and controls (24%), [OR = 0.91, 95% CI (0.55-1.50), P = 0.690]. Glu298 --> Asp polymorphism of the eNOS gene does not appear to be associated with the presence of BD in the Turkish population.

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CRRD Object Information
CRRD ID: 7771577
Created: 2013-12-19
Species: All species
Last Modified: 2013-12-19
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.