The role of endosymbiotic Wolbachia bacteria in the pathogenesis of river blindness.

Authors: Saint Andre, AV  Blackwell, NM  Hall, LR  Hoerauf, A  Brattig, NW  Volkmann, L  Taylor, MJ  Ford, L  Hise, AG  Lass, JH  Diaconu, E  Pearlman, E 
Citation: Saint Andre Av, etal., Science. 2002 Mar 8;295(5561):1892-5.
Pubmed: (View Article at PubMed) PMID:11884755
DOI: Full-text: DOI:10.1126/science.1068732

Parasitic filarial nematodes infect more than 200 million individuals worldwide, causing debilitating inflammatory diseases such as river blindness and lymphatic filariasis. Using a murine model for river blindness in which soluble extracts of filarial nematodes were injected into the corneal stroma, we demonstrated that the predominant inflammatory response in the cornea was due to species of endosymbiotic Wolbachia bacteria. In addition, the inflammatory response induced by these bacteria was dependent on expression of functional Toll-like receptor 4 (TLR4) on host cells.

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CRRD ID: 7794682
Created: 2014-01-08
Species: All species
Last Modified: 2014-01-08
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.