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Enhanced IL-6 production in aquaporin-4 antibody positive neuromyelitis optica patients.

Authors: Icoz, S  Tuzun, E  Kurtuncu, M  Durmus, H  Mutlu, M  Eraksoy, M  Akman-Demir, G 
Citation: Icoz S, etal., Int J Neurosci. 2010 Jan;120(1):71-5. doi: 10.3109/00207450903428970.
Pubmed: (View Article at PubMed) PMID:20128675
DOI: Full-text: DOI:10.3109/00207450903428970

Anti-aquaporin-4 (Aqp-4) antibody and complement system have emerged as major pathogenic factors in neuromyelitis optica (NMO). To test the significance of interleukin-6 (IL-6), another important humoral immunity factor, in NMO pathogenesis, we measured serum and cerebrospinal fluid (CSF) IL-6 levels of 23 NMO, 11 transverse myelitis, 16 optic neuritis, 27 relapsing remitting multiple sclerosis patients, and 20 neurologically normal controls. NMO and transverse myelitis patients had higher serum and CSF IL-6 levels than other groups. Particularly, anti-Aqp-4 positive NMO patients (n = 12) had higher serum/CSF IL-6 levels than anti-Aqp-4 negative patients (n = 11) and CSF IL-6 levels correlated with anti-Aqp-4 levels and disease severity of the NMO patients. Our results suggest that IL-6 is involved in NMO pathogenesis presumably via anti-Aqp-4 associated mechanisms.


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CRRD Object Information
CRRD ID: 7829722
Created: 2014-01-22
Species: All species
Last Modified: 2014-01-22
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.