Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

The assay of interleukin 4 in the serum of normal subjects and atopic patients using a novel immunoassay.

Authors: Jones, KP  Morris, RH  Rolf, S  Whatley, J  Davies, BH 
Citation: Jones KP, etal., Cytokine. 1997 Jul;9(7):529-34.
Pubmed: (View Article at PubMed) PMID:9237816
DOI: Full-text: DOI:10.1006/cyto.1996.0197

Interleukin 4 (IL-4) was measured in the serum of normals and mild atopic patients using a high sensitivity ELISA system involving an amplification stage. The method was found to have a limit of detection of 0.02 pg/ml after a square root transformation of the concentration data and to show good reproducibility with coefficients of variation between 11 and 14%. Recoveries of standard IL-4 from serum was greater than 90%. Markedly elevated levels of IL-4 were seen in the atopic groups compared with the normals. No association was found between total white cell counts, lymphocyte or eosinophil counts and serum IL-4 levels. This study demonstrates that serum IL-4 levels can distinguish between atopic subjects and normals, even in mild or symptomless disease. This may prove valuable in the management of atopic disorders.


Disease Annotations
Objects Annotated

Additional Information

CRRD Object Information
CRRD ID: 7829817
Created: 2014-01-28
Species: All species
Last Modified: 2014-01-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.