Cytokine profiles in aqueous humor of patients with different clinical entities of endogenous uveitis.

Authors: El-Asrar, AM  Struyf, S  Kangave, D  Al-Obeidan, SS  Opdenakker, G  Geboes, K  Van Damme, J 
Citation: El-Asrar AM, etal., Clin Immunol. 2011 May;139(2):177-84. doi: 10.1016/j.clim.2011.01.014. Epub 2011 Jan 31.
Pubmed: (View Article at PubMed) PMID:21334264
DOI: Full-text: DOI:10.1016/j.clim.2011.01.014

We assayed aqueous humor (AH) samples from patients with Behcet's disease (BD), Vogt-Koyanagi-Harada (VKH) disease, and HLA-B27-associated uveitis and control patients for the proinflammatory cytokines IL-15, IL-17, interferon-gamma and tumor necrosis factor-alpha and the immunosuppressive cytokine IL-10. Cytokine levels were significantly higher in the three disease groups than in controls. In patients with similar disease activity, levels of IL-15 and IFN-gamma were significantly higher in BD patients than in VKH and HLA-B27-associated uveitis groups. Logistic regression identified a significant negative correlation between BD and high levels of IL-10 and a significant positive correlation between VKH disease and high levels of IL-10. The proinflammatory cytokines versus IL-10 ratios were significantly higher in BD compared with other groups. These data suggest that both T helper (Th) 1 and Th17 cells are involved in endogenous uveitis immunopathogenesis. BD is characterized by extensive Th1 polarization, severe proinflammatory conditions and a low immunosuppressive status.


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CRRD ID: 8142356
Created: 2014-01-30
Species: All species
Last Modified: 2014-01-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.