Natural killer cell activity, interferon-gamma and antibodies to herpes viruses in patients with Behcet's disease.

Authors: Hamzaoui, K  Ayed, K  Slim, A  Hamza, M  Touraine, J 
Citation: Hamzaoui K, etal., Clin Exp Immunol. 1990 Jan;79(1):28-34.
Pubmed: (View Article at PubMed) PMID:2154346

Interferon-gamma (IFN-gamma) titres in 20 patients with active Behcet's disease were examined and compared with those of 20 normal donors. Sera from Behcet's disease patients revealed an IFN-gamma increase but no correlation between IFN level and natural killer (NK) activity. The analysis of lymphocyte subsets by monoclonal antibodies registered an increase of CD8+ T subpopulation and cells co-expressing CD8(+)-Leu7a+ markers. Moreover, a high number of cells expressing CD25+ and HLA-DR+ phenotype has been noted in patients with active Behcet's disease. Serological analysis showed a high level of IgG antibodies to HSV-1. The increase of IFN-gamma titre, the high number of activated T cells and the increasing level of IgG antibodies to HSV-1 are important manifestations during the active stage of Behcet's disease. These findings are discussed in relation to the immunopathogenesis of Behcet's disease.


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CRRD Object Information
CRRD ID: 8142377
Created: 2014-01-31
Species: All species
Last Modified: 2014-01-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.