Natural killer cell activity, interferon-gamma and antibodies to herpes viruses in patients with Behcet's disease.

Authors: Hamzaoui, K  Ayed, K  Slim, A  Hamza, M  Touraine, J 
Citation: Hamzaoui K, etal., Clin Exp Immunol. 1990 Jan;79(1):28-34.
Pubmed: (View Article at PubMed) PMID:2154346

Interferon-gamma (IFN-gamma) titres in 20 patients with active Behcet's disease were examined and compared with those of 20 normal donors. Sera from Behcet's disease patients revealed an IFN-gamma increase but no correlation between IFN level and natural killer (NK) activity. The analysis of lymphocyte subsets by monoclonal antibodies registered an increase of CD8+ T subpopulation and cells co-expressing CD8(+)-Leu7a+ markers. Moreover, a high number of cells expressing CD25+ and HLA-DR+ phenotype has been noted in patients with active Behcet's disease. Serological analysis showed a high level of IgG antibodies to HSV-1. The increase of IFN-gamma titre, the high number of activated T cells and the increasing level of IgG antibodies to HSV-1 are important manifestations during the active stage of Behcet's disease. These findings are discussed in relation to the immunopathogenesis of Behcet's disease.

Annotation

Disease Annotations
Objects Annotated

Additional Information

 
CRRD Object Information
CRRD ID: 8142377
Created: 2014-01-31
Species: All species
Last Modified: 2014-01-31
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.