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Intrathecal interferon-gamma facilitates the spinal nociceptive flexor reflex in the rat.

Authors: Xu, XJ  Hao, JX  Olsson, T  Kristensson, K  Van der Meide, PH  Wiesenfeld-Hallin, Z 
Citation: Xu XJ, etal., Neurosci Lett. 1994 Dec 5;182(2):263-6.
Pubmed: (View Article at PubMed) PMID:7715823

The effect of intrathecal (i.t.) injection of the cytokine interferon-gamma) (IFN-gamma) on the spinal nociceptive flexor reflex was examined in decerebrate, spinalized, unanesthetized rats. IFN-gamma elicited an initial intense, brief facilitation of the flexor reflex followed by a sustained reflex facilitation lasting 40 +/- 5 min (range 20-65 min). The initial and prolonged reflex facilitations by IFN-gamma were partially and totally blocked, respectively, by i.t. pretreatment with nitro-L-arginine-ester, an inhibitor of nitric oxide synthase, at doses which did not influence spinal cord blood flow. Spinal application of IFN-gamma produced powerful and prolonged facilitation of the flexor reflex, possibly reflecting a hyperalgesic action of this cytokine. The facilitatory effect of IFN-gamma was mediated, at least in part, by the activation of the L-arginine-nitric oxide pathway. Thus, IFN-gamma released in the CNS may participate in eliciting pain and hyperalgesia in infectious or neuroinflammatory diseases where there is increased production of this cytokine.

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CRRD Object Information
CRRD ID: 8158038
Created: 2014-02-05
Species: All species
Last Modified: 2014-02-05
Status: ACTIVE



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