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Lymphokine-induced MHC class II antigen expression on cultured retinal pigment epithelial cells and the influence of cyclosporin A.

Authors: Liversidge, J  Sewell, HF  Thomson, AW  Forrester, JV 
Citation: Liversidge J, etal., Immunology. 1988 Feb;63(2):313-7.
Pubmed: (View Article at PubMed) PMID:3127329

Culture of rat or guinea-pig retinal pigment epithelium (RPE) cells with Con A-induced lymphokine derived from splenic lymphocytes or rat recombinant IFN-gamma induces strong MHC class II (Ia) antigen expression on up to 40% of RPE cells. Cyclosporin A, which inhibits intravitreal inflammation and Ia antigen expression on RPE cells in vivo, despite a choroidal T-cell infiltrate, suppresses production of Ia-inducing lymphokine but does not suppress in vitro responses of RPE cells to preformed lymphokine.


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CRRD Object Information
CRRD ID: 8547557
Created: 2014-02-18
Species: All species
Last Modified: 2014-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.