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Plasma paraoxonase activity and oxidative stress and their relationship to disease severity in children with allergic rhinitis.

Authors: Ozkaya, E  Akduman, H  Erenberk, U  Demir, A  Dundaroz, MR 
Citation: Ozkaya E, etal., Am J Rhinol Allergy. 2013 Jan;27(1):13-7. doi: 10.2500/ajra.2013.27.3837.
Pubmed: (View Article at PubMed) PMID:23406590
DOI: Full-text: DOI:10.2500/ajra.2013.27.3837

BACKGROUND: Oxidative stress may play a role in the pathophysiology of several diseases including allergic rhinitis (AR). In children with AR an antioxidant enzyme paraoxonase (PON1) has not been previously investigated. The aim of this study was to investigate plasma PON1 activity and plasma total oxidant status (TOS), which are in the form of plasma reactive oxidants, and their association with severity of disease in house-mite-sensitive children with AR. METHODS: This study included 66 children with persistent AR and 40 healthy controls aged between 7 and 12 years old. Plasma PON1, TOS, and total serum immunoglobulin E (IgE) were measured. The nasal symptom scores and body mass index were evaluated at the time of blood collection. RESULTS: Mean serum PON1 levels were significantly lower and, TOS levels were higher in the patient group than in the control group (p


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CRRD Object Information
CRRD ID: 8547583
Created: 2014-02-18
Species: All species
Last Modified: 2014-02-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.