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Concentrations of IGF-I and IGFBP-3 and brain tumor risk in the European Prospective Investigation into Cancer and Nutrition.

Authors: Rohrmann, S  Linseisen, J  Becker, S  Allen, N  Schlehofer, B  Overvad, K  Olsen, A  Tjonneland, A  Melin, BS  Lund, E  Vineis, P  Grioni, S  Tumino, R  Palli, D  Mattiello, A  Bonet, C  Chirlaque, MD  Sanchez, MJ  Rodriguez, L  Dorronsoro, M  Ardanaz, E  Lagiou, P  Trichopoulou, A  Trichopoulos, D  Dossus, L  Grote, VA  Boeing, H  Aleksandrova, K  Bueno-de-Mesquita, HB  Van Duijnhoven, FJ  Peeters, PH  Khaw, KT  Wareham, NJ  Key, TJ  Rinaldi, S  Romieux, I  Gallo, V  Michaud, DS  Riboli, E  Kaaks, R 
Citation: Rohrmann S, etal., Cancer Epidemiol Biomarkers Prev. 2011 Oct;20(10):2174-82. doi: 10.1158/1055-9965.EPI-11-0179. Epub 2011 Jul 25.
Pubmed: (View Article at PubMed) PMID:21788435
DOI: Full-text: DOI:10.1158/1055-9965.EPI-11-0179

BACKGROUND: Insulin-like growth factor-1 (IGF-I) is important in normal brain development but in the adult brain, IGF-I overexpression may be a risk factor for tumor development. METHODS: We examined the association between circulating concentrations of IGF-I and IGFBP-3 in relation to risk of gliomas (74 low-grade, 206 high-grade gliomas), meningiomas (n = 174) and acoustic neuromas (n = 49) by using a case-control design nested in the European Prospective Investigation into Cancer and Nutrition. IGF-I and IGFBP-3 were measured by ELISAs.Conditional logistic regression was used to compute ORs and corresponding 95% CIs. RESULTS: The risk of low-grade gliomas was elevated with increased IGF-I (OR = 3.60, 95% CI: 1.11-11.7; top vs. bottom quartile) and decreased with elevated IGFBP-3 concentrations (OR = 0.28, 95% CI: 0.09-0.84) after mutual adjustment of these two factors; these results became nonsignificant after exclusion of the first year of follow-up. No association was observed for high-grade gliomas or meningiomas. Both high IGF-I and IGFBP-3 concentrations were associated with risk of acoustic neuromas (IGF-I: OR = 6.63, 95% CI: 2.27-19.4, top vs. bottom tertile; IGFBP-3: OR = 7.07, 95% CI: 2.32-21.6), even after excluding the first year of follow-up. CONCLUSION: High concentrations of IGF-I might be positively associated with risk of low-grade gliomas and acoustic neuromas, although we cannot exclude reverse causation, in particular for low-grade gliomas. IMPACT: Factors of the IGF axis might be involved in the etiology of some types of brain tumors.


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CRRD Object Information
CRRD ID: 8548833
Created: 2014-03-21
Species: All species
Last Modified: 2014-03-21
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.