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IL-13 gene polymorphisms and their association with atopic asthma and rhinitis in Pakistani patients.

Authors: Shazia, M  Kanza, M  Mehwish, I  Irum, S  Farida, A  Asifa, A 
Citation: Shazia M, etal., Iran J Allergy Asthma Immunol. 2013 Aug 28;12(4):391-6.
Pubmed: (View Article at PubMed) PMID:23996716

Interleukin-13 (IL-13) is known to be a key regulator in immunoglobulin E (IgE) synthesis, mucus hypersecretion and airway hyperresponsiveness. Single nucleotide polymorphisms in IL-13 are associated with allergic phenotypes in several ethnically diverse populations.This study was performed in 214 atopic patients (asthma n=108, allergic rhinitis n=106) and sex-matched healthy controls (n=120). Genotyping of IL-13 gene polymorphisms was performed using polymerase chain reaction-based restriction fragment length polymorphism method.A statistically significant association of the A-1512C polymorphism in IL13 gene was observed with atopy (p<0.001; chi2=19.0). Upon stratification of the data into asthma and AR association was revealed with both asthma (p=0.01; chi2=8.80) and AR (p<0.001; chi2=24.3) in Pakistani patients. Higher odds ratio (OR 95% CI) was observed for AR 3.42 (2.04-5.76) relative to asthma 2.40 (1.41-4.09) for the C allele compared to controls.In conclusion the study provides the evidence A-1512C polymorphisms in IL-13 is a risk factor for asthma and AR.

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CRRD Object Information
CRRD ID: 8549501
Created: 2014-03-27
Species: All species
Last Modified: 2014-03-27
Status: ACTIVE



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