IL-23R gene confers susceptibility to Behcet's disease in a Chinese Han population.

Authors: Jiang, Z  Yang, P  Hou, S  Du, L  Xie, L  Zhou, H  Kijlstra, A 
Citation: Jiang Z, etal., Ann Rheum Dis. 2010 Jul;69(7):1325-8. doi: 10.1136/ard.2009.119420. Epub 2010 Apr 7.
Pubmed: (View Article at PubMed) PMID:20375120
DOI: Full-text: DOI:10.1136/ard.2009.119420

PURPOSE: IL-23 has been shown to be involved in the pathogenesis of Behcet's disease (BD) through promoting IL-17 production. This study examined whether IL-23R polymorphisms were associated with susceptibility to this disease in a Chinese Han population. METHODS: Four single-nucleotide polymorphisms (SNP), rs7517847, rs11209032, rs 1343151 and rs17375018 were genotyped in 338 BD patients and 407 age, sex and ethnically matched healthy controls using a PCR restriction fragment length polymorphism assay. RESULTS: A significantly increased prevalence of the homozygous rs17375018 GG genotype and G allele was found in BD patients compared with controls (corrected p (p(c))<0.001,odds ratio (OR) 1.86, 95% CI 1.39 to 2.49; p(c)<0.001, OR 1.57, 95% CI 1.25 to 1.98, respectively). The frequencies of the AA genotype and A allele of the SNP rs11209032 were significantly higher in BD patients compared with controls (p(c)=0.024, OR 1.69, 95% CI 1.21 to 2.35; p(c)<0.001, OR 1.48, 95% CI 1.21 to 1.82, respectively). In addition, the results showed a significantly decreased frequency of the AGCG haplotype in BD patients compared with controls (p(c)=0.0016, OR 0.59, 95% CI 0.45 to 0.77). CONCLUSIONS: This study, for the first time, identified a strong association of an SNP of IL-23R, rs17375018, with BD. The results also suggested that both rs11209032 AA and rs17375018 GG of IL-23R are predisposing genotypes for BD and that the AGCG haplotype may provide protection against BD.

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CRRD Object Information
CRRD ID: 8549565
Created: 2014-03-31
Species: All species
Last Modified: 2014-03-31
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.