Analysis of the CC chemokine receptor 5 (CCR5) Delta32 polymorphism in Behcet's disease.

Authors: Yang, X  Ahmad, T  Gogus, F  Verity, D  Wallace, GR  Madanat, W  Kanawati, CA  Stanford, MR  Fortune, F  Jewell, DP  Marshall, SE 
Citation: Yang X, etal., Eur J Immunogenet. 2004 Feb;31(1):11-4.
Pubmed: (View Article at PubMed) PMID:15009175

Chemokines are important determinants of the early inflammatory response. The CC chemokine receptor 5 (CCR5) Delta32 variant results in a non-functional form of the chemokine receptor, and has been implicated in a variety of immune-mediated diseases. To investigate its role in the pathogenesis of Behcet's disease, we studied 350 patients and 519 healthy controls from three ethnic groups. While significant inter-ethnic variation in allele frequency was observed, no association was identified with disease, even when data were stratified by the known susceptibility gene HLA-B*51.


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CRRD Object Information
CRRD ID: 8551827
Created: 2014-04-14
Species: All species
Last Modified: 2014-04-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.