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Caveolin-3 is associated with the T-tubules of mature skeletal muscle fibers.

Authors: Ralston, E  Ploug, T 
Citation: Ralston E and Ploug T, Exp Cell Res. 1999 Feb 1;246(2):510-5.
Pubmed: (View Article at PubMed) PMID:9925767
DOI: Full-text: DOI:10.1006/excr.1998.4305

Caveolae are abundant in skeletal muscle and their coat contains a specific isoform of caveolin, caveolin-3. It has been suggested that during muscle development, caveolin-3 is associated with the T-tubules, but that in adult muscle it is found on the plasma membrane only. We have studied the distribution of caveolin-3 in single skeletal muscle fibers from adult rat soleus by confocal immunofluorescence and by immunogold electron microscopy. We found that caveolin-3 occurs at the highest density on the plasma membrane but is also present in the core of the fibers, at the I-band/A-band interface where it is associated with the T-tubules. In neither domain of the muscle surface does caveolin-3 colocalize with the glucose transporter GLUT4 and there is no evidence for internalization of the caveolae in muscle.

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CRRD Object Information
CRRD ID: 8553487
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE



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