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A calcium-regulated MEF2 sumoylation switch controls postsynaptic differentiation.

Authors: Shalizi, A  Gaudilliere, B  Yuan, Z  Stegmuller, J  Shirogane, T  Ge, Q  Tan, Y  Schulman, B  Harper, JW  Bonni, A 
Citation: Shalizi A, etal., Science. 2006 Feb 17;311(5763):1012-7.
Pubmed: (View Article at PubMed) PMID:16484498
DOI: Full-text: DOI:10.1126/science.1122513

Postsynaptic differentiation of dendrites is an essential step in synapse formation. We report here a requirement for the transcription factor myocyte enhancer factor 2A (MEF2A) in the morphogenesis of postsynaptic granule neuron dendritic claws in the cerebellar cortex. A transcriptional repressor form of MEF2A that is sumoylated at lysine-403 promoted dendritic claw differentiation. Activity-dependent calcium signaling induced a calcineurin-mediated dephosphorylation of MEF2A at serine-408 and, thereby, promoted a switch from sumoylation to acetylation at lysine-403, which led to inhibition of dendritic claw differentiation. Our findings define a mechanism underlying postsynaptic differentiation that may modulate activity-dependent synapse development and plasticity in the brain.

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CRRD Object Information
CRRD ID: 8553655
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE



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