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Intersectin 1 forms a complex with adaptor protein Ruk/CIN85 in vivo independently of epidermal growth factor stimulation.

Authors: Nikolaienko, O  Skrypkina, I  Tsyba, L  Fedyshyn, Y  Morderer, D  Buchman, V  De la Luna, S  Drobot, L  Rynditch, A 
Citation: Nikolaienko O, etal., Cell Signal. 2009 May;21(5):753-9. doi: 10.1016/j.cellsig.2009.01.013. Epub 2009 Jan 8.
Pubmed: (View Article at PubMed) PMID:19166927
DOI: Full-text: DOI:10.1016/j.cellsig.2009.01.013

Intersectin 1 (ITSN1) is an adaptor protein involved in clathrin-mediated endocytosis, apoptosis, signal transduction and cytoskeleton organization. Here, we show that ITSN1 forms a complex with adaptor protein Ruk/CIN85, implicated in downregulation of receptor tyrosine kinases. The interaction is mediated by the SH3A domain of ITSN1 and the third or fourth proline-rich blocks of Ruk/CIN85, and does not depend on epidermal growth factor stimulation, suggesting a constitutive association of ITSN1 with Ruk/CIN85. Moreover, both proteins colocalize in MCF-7 cells with their common binding partner, the ubiquitin ligase c-Cbl. The possible biological role of the interaction between ITSN1 and Ruk/CIN85 is discussed.


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CRRD Object Information
CRRD ID: 8553728
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.