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The microtubule associated protein syntabulin is required for glucose-stimulated and cAMP-potentiated insulin secretion.

Authors: Ying, Y  Li, L  Cao, W  Yan, D  Zeng, Q  Kong, X  Lu, L  Yan, M  Xu, X  Qu, J  Su, Q  Ma, X 
Citation: Ying Y, etal., FEBS Lett. 2012 Oct 19;586(20):3674-80. doi: 10.1016/j.febslet.2012.08.025. Epub 2012 Sep 6.
Pubmed: (View Article at PubMed) PMID:22975310
DOI: Full-text: DOI:10.1016/j.febslet.2012.08.025

Syntabulin is a microtubule-associated protein that mediates anterograde transport of vesicles to neuronal processes. Here, we found that syntabulin was expressed in mouse pancreas and insulin-secreting beta-cells, and that it partially co-localized with microtubule and insulin-containing granules. The association of syntabulin with these organelles increased upon glucose stimulation. Knock-down of syntabulin by shRNA reduced both basal and glucose-stimulated insulin secretion, and diminished cAMP-Epac2 and cAMP-PKA potentiated insulin secretion. Additionally, syntabulin was preferentially phosphorylated by the Epac2 agonist 8-pCPT-2'-O-Me-cAMP, suggesting that syntabulin could be a novel effector of Epac2 and play a critical role in cAMP-enhanced insulin secretion.

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CRRD Object Information
CRRD ID: 8554225
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE



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