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Protrudin induces neurite formation by directional membrane trafficking.

Authors: Shirane, M  Nakayama, KI 
Citation: Shirane M and Nakayama KI, Science. 2006 Nov 3;314(5800):818-21.
Pubmed: (View Article at PubMed) PMID:17082457
DOI: Full-text: DOI:10.1126/science.1134027

Guanosine triphosphatases of the Rab family are key regulators of membrane trafficking, with Rab11 playing a specific role in membrane recycling. We identified a mammalian protein, protrudin, that promoted neurite formation through interaction with the guanosine diphosphate (GDP)-bound form of Rab11. Phosphorylation of protrudin by extracellular signal-regulated kinase (ERK) in response to nerve growth factor promoted protrudin association with Rab11-GDP. Down-regulation of protrudin by RNA interference induced membrane extension in all directions and inhibited neurite formation. Thus, protrudin regulates Rab11-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation.


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CRRD Object Information
CRRD ID: 8554602
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.