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Activin isoforms signal through type I receptor serine/threonine kinase ALK7.

Authors: Tsuchida, K  Nakatani, M  Yamakawa, N  Hashimoto, O  Hasegawa, Y  Sugino, H 
Citation: Tsuchida K, etal., Mol Cell Endocrinol. 2004 May 31;220(1-2):59-65.
Pubmed: (View Article at PubMed) PMID:15196700
DOI: Full-text: DOI:10.1016/j.mce.2004.03.009

Activins play a fundamental role in cell differentiation and development. Activin A signaling is mediated through a combination of activin type II receptors (ActRIIs) and the activin type IB receptor, ALK4. Signaling receptors of other activin isoforms remain to be elucidated. Here, we found that activin AB and activin B are ligands for ALK7. ALK7 is an orphan receptor serine/threonine kinase expressed in neuroendocrine tissues including pancreatic islets. The combination of ActRIIA and ALK7, preferred by activin AB and activin B but not by activin A, is responsible for activin-mediated secretion of insulin from pancreatic beta cell line, MIN6. In contrast, all activins activate a combination of ActRIIA and ALK4 with various levels of potency. Thus, variation in activin signaling through type I receptors is dependent upon homo- and heterodimeric assembly of activin isoforms. Thus, the differential combination of receptor heterodimers mediates variation in activin isoform signaling.

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CRRD Object Information
CRRD ID: 8554721
Created: 2014-05-08
Species: All species
Last Modified: 2014-05-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.