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Cocaine self-administration alters brain NADH dehydrogenase mRNA levels.

Authors: Couceyro, P  Shoaib, M  McCoy, M  Goldberg, SR  Kuhar, MJ 
Citation: Couceyro P, etal., Neuroreport. 1997 Jul 28;8(11):2437-41.
Pubmed: (View Article at PubMed) PMID:9261805

Using differential display PCR, we identified a cDNA whose expression is altered in several brain regions in rats self-administering cocaine. The cDNA sequence corresponds to bases 13687-13723 of the rat NADH dehydrogenase subunit 6 gene. Northern analysis indicated a 26% decrease in nucleus accumbens, a 305% increase in the ventral midbrain and no changes in the caudate putamen mRNA levels; changes were also noted in the hypothalamus and cerebellum. This is the first demonstration of an effect of cocaine self-administration on mitochondrial gene expression and suggests that regional metabolic changes elicited by cocaine may be relevant to and involved in its reinforcing properties.


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CRRD Object Information
CRRD ID: 8657132
Created: 2014-06-03
Species: All species
Last Modified: 2014-06-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.