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[Molecular biological study of aloe vera in the treatment of experimental allergic rhinitis in rat].

Authors: Yu, Hongwei  Dong, Zhen  Yang, Zhanquan 
Citation: Yu H, etal., Lin Chuang Er Bi Yan Hou Ke Za Zhi. 2002 May;16(5):229-31.
Pubmed: (View Article at PubMed) PMID:12592663

OBJECTIVE: To study the therapeutic mechanism of aloe vera in allergic rhinitis (AR).
METHOD: Ovalbumin sensitized white rat used as animal models of AR were treated intranasally with aloe vera. At the end of treatment, the differences in the behavior science were observed; the changes in the nasal mucosa were studied by pathological; IL-2, IL-4 mRNA in the nasal mucosa and spleen were used to do reverse transcriptive polymerase chain reaction (RT-PCR).
RESULT: The behavior science score of positive controls (8.42 +/- 1.06) was higher than the experimental group (2.02 +/- 0.42) and normal controls (0); inflammatory reactions in the experimental group nasal mucosa were remarkably relieved; the mean expression level of IL-2 mRNA in the experimental group was higher significantly than positive controls (P < 0.01); but that of IL-4 mRNA was lower evidently (P < 0.01).
CONCLUSION: The aloe vera are suggested to be involved in the differentiation of CD4+ lymphocytes, by means of regulating the expression of Th1 and Th2 cytokines. The results suggests that local aloe vera treatment was a selective and non-traumatic method to treat the allergic rhinitis.


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CRRD Object Information
CRRD ID: 8662963
Created: 2014-06-30
Species: All species
Last Modified: 2016-12-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.