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Spinal injection of IL-2 or IL-15 alters mechanical and thermal withdrawal thresholds in rats.

Authors: Cata, JP  Weng, HR  Dougherty, PM 
Citation: Cata JP, etal., Neurosci Lett. 2008 May 23;437(1):45-9. doi: 10.1016/j.neulet.2008.03.074. Epub 2008 Mar 29.
Pubmed: (View Article at PubMed) PMID:18423867
DOI: Full-text: DOI:10.1016/j.neulet.2008.03.074

IL-2 and IL-15 were tested for effects on responses to mechanical or thermal stimuli when spinally administered to male Sprague-Dawley rats with surgically implanted intrathecal catheters. Restricted doses of both IL-2 and IL-15 produced increased responsiveness to mechanical stimulation of the hindpaws. This effect lasted up to 48 h. IL-2 had biphasic effects on thermal responses whereas IL-15 produced thermal hypalgesia alone. These effects dissipated within 24h. These results suggest that IL-2 and IL-15 may participate in the generation of hyperalgesia in some pain conditions.

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CRRD Object Information
CRRD ID: 8662980
Created: 2014-07-01
Species: All species
Last Modified: 2014-07-01
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.