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Interleukin-17A expression in patients presenting with nasal polyposis.

Authors: Avelino, MA  Wastowski, IJ  Ferri, RG  Elias, TG  Lima, AP  Nunes, LM  Pignatari, SS 
Citation: Avelino MA, etal., Braz J Otorhinolaryngol. 2013 Sep-Oct;79(5):616-9. doi: 10.5935/1808-8694.20130110.
Pubmed: (View Article at PubMed) PMID:24141678
DOI: Full-text: DOI:10.5935/1808-8694.20130110

Sinonasal polyposis (SNP) is a chronic inflammatory pathology of the nasal/paranasal cavities which affects from 1%-4% of the population. Although polyps seem to be a manifestation of chronic inflammation of nasal/paranasal sinus mucosa in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown. Interleukin-17A (IL-17A) is a key inflammatory cytokine in many disorders. Little attention has been paid to the role of IL-17A in chronic inflammatory disorders. OBJECTIVE: To investigate the expression of IL-17A in the SNP and verify if this expression is a marker of good or bad prognosis. METHOD: Prospective study with 25 patients presenting with SNP were subjected to the immunohistochemistry technique. After a skin prick test, all patients were divided into atopic and nonatopic groups, and asthmatic or non-asthmatic. RESULTS: The IL-17A expression was observed in both atopic and nonatopic patients. The numbers of IL-17A positive cells were greater in nasal polyps of atopic patients than nonatopic (p = 0.0128). CONCLUSION: These results indicate that IL-17A may play an important role in the pathology of SNP. Considering the inflammatory properties of IL-17A, this study suggests that it could increase susceptibility to atopy and asthma.


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CRRD Object Information
CRRD ID: 9068428
Created: 2014-08-18
Species: All species
Last Modified: 2014-08-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.