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Reduced microglial CX3CR1 expression delays neurofibromatosis-1 glioma formation.

Authors: Pong, WW  Higer, SB  Gianino, SM  Emnett, RJ  Gutmann, DH 
Citation: Pong WW, etal., Ann Neurol. 2013 Feb;73(2):303-8. doi: 10.1002/ana.23813. Epub 2013 Feb 19.
Pubmed: (View Article at PubMed) PMID:23424002
DOI: Full-text: DOI:10.1002/ana.23813

Although traditional models of carcinogenesis have largely focused on neoplastic cells, converging data have revealed the importance of non-neoplastic stromal cells in influencing tumor growth and progression. Leveraging a genetically engineered mouse model of neurofibromatosis type 1 (NF1)-associated optic glioma, we now demonstrate that stromal microglia express the CX3CR1 chemokine receptor, such that reduced CX3CR1 expression decreases optic nerve microglia. Moreover, genetic reduction of Cx3cr1 expression in Nf1 optic glioma mice delays optic glioma formation. Coupled with previous findings demonstrating that microglia maintain optic glioma growth, these new findings provide a strong preclinical rationale for the development of future stroma-directed glioma therapies in children.

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CRRD Object Information
CRRD ID: 9491391
Created: 2014-09-09
Species: All species
Last Modified: 2014-09-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.