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Aberrant epigenetic regulation of bromodomain BRD4 in human colon cancer.

Authors: Rodriguez, RM  Huidobro, C  Urdinguio, RG  Mangas, C  Soldevilla, B  Dominguez, G  Bonilla, F  Fernandez, AF  Fraga, MF 
Citation: Rodriguez RM, etal., J Mol Med (Berl). 2012 May;90(5):587-95. doi: 10.1007/s00109-011-0837-0. Epub 2011 Nov 27.
Pubmed: (View Article at PubMed) PMID:22120039
DOI: Full-text: DOI:10.1007/s00109-011-0837-0

The bromodomain protein BRD4 is involved in cell proliferation and cell cycle progression, primarily through its role in acetylated chromatin-dependent regulation of transcription at targeted loci. Here, we show that BRD4 is frequently downregulated by aberrant promoter hypermethylation in human colon cancer cell lines and primary tumors. Ectopic re-expression of BRD4 in these colon cancer cell lines markedly reduced in vivo tumor growth, suggesting a role of BRD4 in human colon cancer.


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CRRD Object Information
CRRD ID: 9586351
Created: 2014-09-29
Species: All species
Last Modified: 2014-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.