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Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer.

Authors: Li, W  Zhao, L  Zang, W  Liu, Z  Chen, L  Liu, T  Xu, D  Jia, J 
Citation: Li W, etal., Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):372-8. doi: 10.1016/j.bbrc.2011.11.045. Epub 2011 Nov 19.
Pubmed: (View Article at PubMed) PMID:22133676
DOI: Full-text: DOI:10.1016/j.bbrc.2011.11.045

Epigenetic alterations such as aberrant expression of histone-modifying enzymes have been implicated in tumorigenesis. Jumonji domain containing 2B (JMJD2B) is a newly identified histone demethylase that regulates chromatin structure or gene expression by removing methyl residues from trimethylated lysine 9 on histone H3. Recent observations have shown oncogenic activity of JMJD2B. We explored the functional role of JMJD2B in cancer cell proliferation, survival and tumorigenesis, and determined its expression profile in gastric cancer. Knocking down JMJD2B expression by small interfering RNA (siRNA) in gastric and other cancer cells inhibited cell proliferation and/or induced apoptosis and elevated the expression of p53 and p21(CIP1) proteins. The enhanced p53 expression resulted from activation of the DNA damage response pathway. JMJD2B knockdown markedly suppressed xenograft tumor growth in vivo in mice. Moreover, JMJD2B expression was increased in primary gastric-cancer tissues of humans. Thus, JMJD2B is required for sustained proliferation and survival of tumor cells in vitro and in vivo, and its aberrant expression may contribute to the pathogenesis of gastric cancer.

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CRRD Object Information
CRRD ID: 9587739
Created: 2014-10-16
Species: All species
Last Modified: 2014-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.