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RNA polymerase I termination: Where is the end?

Authors: Nemeth, A  Perez-Fernandez, J  Merkl, P  Hamperl, S  Gerber, J  Griesenbeck, J  Tschochner, H 
Citation: Nemeth A, etal., Biochim Biophys Acta. 2013 Mar-Apr;1829(3-4):306-17. doi: 10.1016/j.bbagrm.2012.10.007. Epub 2012 Oct 23.
Pubmed: (View Article at PubMed) PMID:23092677
DOI: Full-text: DOI:10.1016/j.bbagrm.2012.10.007

The synthesis of ribosomal RNA (rRNA) precursor molecules by RNA polymerase I (Pol I) terminates with the dissociation of the protein-DNA-RNA ternary complex. Based on in vitro results the mechanism of Pol I termination appeared initially to be rather conserved and simple until this process was more thoroughly re-investigated in vivo. A picture emerged that Pol I termination seems to be connected to co-transcriptional processing, re-initiation of transcription and, possibly, other processes downstream of Pol I transcription units. In this article, our current understanding of the mechanism of Pol I termination and how this process might be implicated in other biological processes in yeast and mammals is summarized and discussed. This article is part of a Special Issue entitled: Transcription by Odd Pols.


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CRRD Object Information
CRRD ID: 9588249
Created: 2014-10-23
Species: All species
Last Modified: 2014-10-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.