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[Expressions of Jumonji domain containing protein 2C and hypoxia-inducible factor-1alpha in gastric carcinoma and their clinical significance].

Authors: Xu, Y  Yao, HB  Jin, Y  Ma, YY  Wang, HJ  Shao, QS 
Citation: Xu Y, etal., Zhonghua Yi Xue Za Zhi. 2013 Nov 12;93(42):3375-8.
Pubmed: (View Article at PubMed) PMID:24418035

OBJECTIVE: To explore the expressions of Jumonji domain containing protein 2C (JMJD2C) and hypoxia-inducible factor-1 alpha (HIF-1alpha) in gastric carcinoma and their relationship with clinicopathological characteristics. METHODS: A retrospective cohort study was performed for 110 gastric cancer (GC) patients at Zhejiang Provincial People's Hospital from 2005 to 2007. There were 78 males and 32 females with an average age of 57 (32-79) years. There was no preoperative radiochemotherapy.Immunohistochemical analysis was used to evaluate the expressions of JMJD2C and HIF-1alpha in 110 specimens of gastric cancer tissues and 80 normal adjacent tissues. RESULTS: The positive expression rates of JMJD2C and HIF-1alpha in GC (69.1% (76/110) and 73.6% (81/110) ) were significantly higher than those in normal tissues (both 0, both P < 0.05). The positive expression of JMJD2C in GC was significantly correlated with TNM stage, invasive depth, lymph node metastasis and distant metastasis (all P < 0.05). The positive expression of HIF-1alpha was significantly correlated with TNM stage, invasive depth, lymph node metastasis and distant metastasis (all P < 0.05).JMJD2C expression was positively correlated with HIF-1alpha expression (r = 0.219, P < 0.05) . The survival time of JMJD2C positive group and HIF-1alpha positive group were significantly shorter than those of the negative group ( (38 +/- 4) vs (56 +/- 6) months, (38 +/- 4) vs (60 +/- 6) months, chi(2) = 8.006, 7.218, both P < 0.01). The survival time of group positive in both JMJD2C and HIF-1alpha was significantly shorter than that of single positive or double negative groups (chi(2) = 10.425, P < 0.01). CONCLUSIONS: The over-expressions of JMJD2C and HIF-1alpha in gastric cancer tissues play a role in the growth, invasion and metastasis of gastric tumor. Both may be used to predict the prognosis of GC patients.

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CRRD Object Information
CRRD ID: 9588260
Created: 2014-10-23
Species: All species
Last Modified: 2014-10-23
Status: ACTIVE



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